T. Denny Sanford, South Dakota Philanthropist and Business Leader, Dies at 90

Northeast Radio SD News – South Dakota  - First PREMIER Bank, PREMIER Bankcard, and Sanford Health have announced the passing of T. Denny Sanford, the South Dakota business leader and nationally recognized philanthropist whose giving reshaped health care, education, and community development across the region. He was 90.

In a joint statement, the organizations said Sanford “wanted to live a life of significance and gave generously,” noting that his philanthropy “impacted millions of lives and transformed the landscape of South Dakota and beyond.”

Sanford, whose name is attached to world‑class medical facilities, research institutes, university programs, and countless community initiatives, leaves behind a legacy defined by bold investments in people and institutions. His approach to giving — often focused on large‑scale, future‑oriented projects — made him one of the most influential donors in state history.

Leaders Reflect on a Legacy of Significance

Dana Dykhouse, CEO of First PREMIER Bank, said Sanford’s drive to help others was evident from the moment they met.

“Denny’s passion for helping people and inspiring others to do the same is unmatched. He often said many people live a life of success, but you should try to live a life of significance where you can make an impact on people.”

Miles Beacom, CEO of PREMIER Bankcard, emphasized Sanford’s role in strengthening South Dakota’s institutions.

“Denny changed the landscape of giving. He could have done many things with his money, yet he reinvested it in South Dakota. Our universities are stronger today because of Denny. Our health care is stronger today because of Denny. He believed in working harder to help someone other than yourself.”

At Sanford Health, leaders say his support accelerated medical innovation and expanded care for families across the region.

“We are forever blessed that Denny chose us and our communities to make the transformational gifts that will change lives for generations,” said Bill Gassen, President and CEO of Sanford Health. “He was a driving force in modern medicine, empowering researchers and clinicians to think big and pursue bold, innovative endeavors at a pace not otherwise possible.”

A Philanthropic Force Who Reinvested in His Home State

Sanford’s giving touched nearly every corner of South Dakota life — from children’s hospitals and medical research to scholarships, workforce development, and community programs. His philosophy centered on creating long‑term, structural improvements that would benefit future generations.

His contributions helped elevate Sioux Falls and the surrounding region into a national hub for health care innovation, while also strengthening rural access to care. Universities across the state credit Sanford with expanding academic programs, research capacity, and student opportunities.

A Life That Will Continue to Shape the Future

As communities reflect on Sanford’s passing, leaders say his influence will endure through the institutions he strengthened and the people whose lives were changed by his generosity.

“Denny always said he wanted to live a life of significance,” the joint statement read. “He achieved that — and more.”